Our study revealed that the lowest albumin level within 1 week after admission was independently associated with mortality in severe acute pancreatitis (SAP).

In addition, infusing albumin may decrease mortality for hypoalbuminemia patients with SAP.

In addition, infusing a sufficient albumin dose within a week after admission may decrease mortality for hypoalbuminemia patients treated with albumin infusions.

Certainly, further prospective studies are required to confirm the clinical application of human serum albumin in SAP.

This was a retrospective cohort study that analyzed 1000 patients with SAP who were admitted to the First Affiliated Hospital of Nanchang University between January 2010 and December 2021 using data from a prospectively maintained database.

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