Association Between Incident Delirium Treatment with Haloperidol and Mortality in Critically Ill Adults

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Treatment of incident delirium and its symptoms with haloperidol may be associated with a dose-dependent improvement in survival. Future randomized trials need to confirm these results.

Patients were evaluated tid for delirium and coma for 28 days.

Patients received preventive haloperidol or placebo for up to 28 days until delirium occurrence, death, or ICU discharge.

Time-varying Cox hazards models were constructed for 28-day and 90-day mortality, controlling for study-arm, delirium and coma days, age, Acute Physiology and Chronic Health Evaluation-II score, sepsis, mechanical ventilation, and ICU length of stay.

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