Use of the novel dose-effect index, Blood Pressure Response Index (BPRI) was proposed to allow rapid bedside assessment of the reactivity of septic shock patients to vasoactive drugs, as isolated MAP or VIS cannot reflect this feature.

BPRI had a comparable AUROC than SOFA and APS for predicting in-hospital mortality and was more user-friendly and efficient.

Also, the BPRI demonstrated a significant cut-off value in predicting prognosis, with patients less than the cut-off value having a significantly higher risk of death. Short-term changes in BPRI could be influenced by lactate level, the cumulative 12-h fluid balance, and related measures.

The application of BPRI and other factors influencing short-term changes in the clinical setting could help clinicians identify potentially at-risk patients and provide clues for treating the early stage of sepsis.

Future research is needed to determine whether BPRI could be used as a target for intervention in patients with sepsis.

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