Possibly, the future of research and clinical practice is not conceived as a confrontation between Randomized control trial (RCT) and observational studies, but rather as the sum of knowledge between RCTs and its clinical application.

According to the RECOVERY trial results, an adaptive RCT, during the second pandemic wave, corticosteroid use was generalized in all critical COVID-19 patients.

However, the role of corticosteroids in the treatment of COVID-19 remains controversial.

A recent study comparing first versus second wave reported that, despite of the systematic and early administration of glucocorticoids in the second wave, the ICU mortality and of ICU length of stay did not differ between the two waves.

Read More