Dual Therapy Using Sildenafil and Milrinone Superior to Monotherapy in Neonates with Severe PPHN

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Dual therapy using sildenafil and milrinone was superior to monotherapy with either drug in neonates with severe persistent pulmonary hypertension (PPHN) and is recommended for use in resource-constrained settings.

A double-blind randomized controlled trial was conducted in which neonates with PPHN.

Post-treatment pulmonary artery systolic pressure was significantly lower in group 3 than in groups 1 and 2, which both received monotherapy.

The oxygenation index also decreased significantly in the dual-therapy group compared with the monotherapy groups.

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