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Dual Therapy Using Sildenafil and Milrinone Superior to Monotherapy in Neonates with Severe PPHN

Dual Therapy Using Sildenafil and Milrinone Superior to Monotherapy in Neonates with Severe PPHN

Dual therapy using sildenafil and milrinone was superior to monotherapy with either drug in neonates with severe persistent pulmonary hypertension (PPHN) and is recommended for use in resource-constrained settings.

A double-blind randomized controlled trial was conducted in which neonates with PPHN.

Post-treatment pulmonary artery systolic pressure was significantly lower in group 3 than in groups 1 and 2, which both received monotherapy.

The oxygenation index also decreased significantly in the dual-therapy group compared with the monotherapy groups.

CriticalCare.news
September 24, 2020

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