Early vs. Delayed Administration of Norepinephrine in Patients with Septic Shock

ncbi.nlm.nih.gov October 28, 2019

early-versus-delayed-administration-of-norepinephrine-in-patients-with-septic-shock

This study investigated the incidence of delayed norepinephrine administration following the onset of septic shock and its effect on hospital mortality.

Our results show that early administration of norepinephrine in septic shock patients is associated with an increased survival rate.

The 28-day mortality was 37.6% overall.

Among the 213 patients, a strong relationship between delayed initial norepinephrine administration and 28-day mortality was noted.

Every 1-hour delay in norepinephrine initiation during the first 6 hours after septic shock onset was associated with a 5.3% increase in mortality.

28 day mortality rates were significantly higher when norepinephrine administration was started more than or equal to 2 hours after septic shock onset (Late-NE) compared to less than 2 hours (Early-NE).