In a population-based registry, 4% of out-of-hospital cardiac arrests (OHCA) were treated with extracorporeal-CPR, which was not associated with increased hospital survival.

Early extracorporeal membrane oxygenation (ECMO) implantation may improve outcomes.

The initial rhythm and ROSC may help select patients for extracorporeal-CPR.

We analysed a prospective registry of 13,191 OHCAs in the Paris region from May 2011 to January 2018.

We compared survival at hospital discharge with and without extracorporeal-CPR and identified factors associated with survival in patients given extracorporeal-CPR.

Survival was 8% in 525 patients given extracorporeal-CPR and 9% in 12,666 patients given conventional-CPR.

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