Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

bmcinfectdis.biomedcentral.com August 9, 2023

The prevalence of antimicrobial de-escalation (ADE) strategy was low among intensive care unit patients. The ADE strategy demonstrated a protective effect or no adverse effect on 14-day mortality compared to the No Change or Other Change strategies, respectively.

These findings provide evidence supporting the implementation of the ADE strategy in ICU patients.

A total of 473 patients met the inclusion criteria, with 53 (11.2%) in the ADE group, 173 (36.6%) in the No Change group, and 247 (52.2%) in the Other Change group.

The 14-day mortality rates in the three groups were 9.4%, 11.6%, and 21.9%, respectively.

After IPTW, the adjusted odds ratio for 14-day mortality comparing No Change with ADE was 1.557 (95% CI 1.078–2.247, P = 0.0181) while comparing Other Change with ADE was 1.282(95% CI 0.884–1.873, P = 0.1874).