Epinephrine administered during in-hospital resuscitation was associated with lower 7-day survival rate in patients with out-of-hospital cardiac arrest (OHCA) following trauma.

While we examined the outcomes of selected patients with limited data that were lacking critical information related to resuscitation of injured patients, we recommend that epinephrine should be deliberately used during the resuscitation of patients with traumatic OHCA.

Further studies should be undertaken to confirm the unfavourable effects of epinephrine among patients with traumatic OHCA.

Of the 1,125 adults with traumatic OHCA during the study period, 1030 patients were included in this study.

Among them, 822 (79.8%) were resuscitated using epinephrine, and 1.1% in the epinephrine group and 5.3% in the no-epinephrine group survived 7 days after injury.

This study is a post-hoc analysis of a prospective, multicentre, observational study on patients with out-of-hospital cardiac arrest (OHCA) between January 2012 and March 2013.

We included adult patients with traumatic OHCA who were aged ≥15 years and excluded those with missing survival data.

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