FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC)

ccforum.biomedcentral.com
first-line-support-for-assistance-in-breathing-in-children-first-abc

A multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in pediatric critical care. Our pilot trial confirms that, following minor changes to consent procedures and treatment algorithms, it is feasible to conduct a large national RCT of non-invasive respiratory support in the pediatric critical care setting in both step-up and step-down NRS patients. Overall, 121/254 eligible patients (47.6%) were randomised (Group A 60%, Group B 44.2%) over a 10-month period (recruitment rate for Group A, 1 patient/site/month; Group B, 2.8 patients/site/month).

Read More