This is the largest adult cohort study focusing on the neurologic complications and mortality after hypernatremia correction in critically ill adults.

There wasn’t any evidence that rapid correction of hypernatremia was associated with a higher risk for mortality, or neurological sequelae (seizure, alteration of consciousness, and/or cerebral edema) in critically ill adult patients with either admission or hospital-acquired hypernatremia.

The latter result is based on a the manual review performed by the authors.

This retrospective study adds to the existing literature which has consistently been unable to show any reduction in adverse neurologic (or other) outcomes with slow correction of hypernatremia.

In addition, as seen in two prior studies, there was a trend towards harm with slow correction.

It is contrast to the study done in neonates which did report a higher risk of death and convulsions with rapid correction.

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