Lung-protective ventilation for acute respiratory distress syndrome (ARDS) aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation.

This study indicates lung-protective properties of a controlled expiration beyond VT and inspiratory pressure limitation in an animal model of ARDS.

Further investigations of a controlled expiration and its therapeutic potential for the treatment of ARDS are necessary.

Pao2 and Paco2, minute volume, tracheal pressure, lung aeration measured via CT, alveolar wall thickness, cell infiltration, and surfactant protein A concentration in bronchoalveolar lavage fluid.

Five pigs were excluded leaving n equals to 7 for each group.

Compared with control, flow-controlled ventilation elevated Pao2 and achieved comparable Paco2 with a lower minute volume.

The study was approved by the appropriate governmental body (Regierungspräsidium Freiburg, file reference G-16/77) and conducted in accordance with the European law on the protection of animals used for scientific purposes.

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