This nICP estimation algorithm, based on arterial blood pressure (ABP) and bedside transcranial Doppler (TCD) cerebral blood flow velocity (CBFV) waveform measurements, performs in a manner comparable to invasive intracranial pressure (ICP) monitoring.

These findings open the possibility for rational, point-of-care treatment decisions in pediatric patients with suspected raised ICP undergoing intensive care.

Invasive ICP and ABP recordings were collected from 12 pediatric and young adult patients (aged 2-25 years) undergoing such monitoring as part of routine clinical care.

Additionally, simultaneous TCD ultrasonography-based middle cerebral artery (MCA) CBFV waveform measurements were performed at the bedside in dedicated data collection sessions.

Greater than 80% of all nICP estimates fell within ± 7 mm Hg of the reference measurement.

Overall performance in the nonoverlapping data window approach gave a mean error (bias) of 1.0 mm Hg, standard deviation of the error (precision) of 5.1 mm Hg, and root-mean-square error of 5.2 mm Hg.

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