Haloperidol for the Management of Delirium in Adult ICU Patients

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haloperidol-for-the-management-of-delirium-in-adult-icu-patients

Among critically ill patients, haloperidol administration compared with placebo does not significantly affect short-term mortality, incidence of delirium, ICU length of stay, or delirium or coma-free days. Additionally, there was no increased risk of adverse events. Six RCTs representing 2552 patients. There was no significant difference between haloperidol and placebo-treated patients in short-term all-cause mortality, incidence of delirium, ICU length of stay, or delirium/coma-free days. Haloperidol was not associated with increased risk for serious adverse events, QTc prolongation, or extrapyramidal symptoms. Our study is a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing haloperidol versus placebo for treatment and/or prophylaxis of ICU-related delirium.

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