Hemodynamic Stabilization Using CRRT and cIVNa Combination Therapy

onlinelibrary.wiley.com April 22, 2025

Compared with conventional continuous renal replacement therapy (CRRT), combination therapy of CRRT and continuous intravenous sodium infusion therapy (cIVNa) increased blood pressure, enhanced urinary volume, and reduced hypotension events, indicating hemodynamic stabilization.

Furthermore, this intervention significantly improved clinical outcomes, including 90-day survival rate, 60-day and 90-day survival rate without renal replacement therapy (RRT), survival discharge rate from ICU, CRRT withdrawal rate, and RRT withdrawal rate.

These findings suggest that combination therapy may be a useful treatment option for hemodynamically unstable patients with AKI requiring CRRT, particularly those with expected insufficient plasma refilling.

The clinical data of 92 patients were analyzed. Clinical data from the control (CRRT, n = 49) and intervention (CRRT + cIVNa, n = 43) groups were compared statistically.