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Impact of Paralytic Agent on Postintubation Sedation

Impact of Paralytic Agent on Postintubation Sedation

The aim of this study was to evaluate the difference in the time to postintubation sedation between patients receiving etomidate and either succinylcholine or rocuronium in the prehospital setting.

This study suggests rocuronium’s long duration of effect puts patients at risk for wakeful paralysis once the short effects of etomidate have subsided.

64 and 38 patients received succinylcholine or rocuronium, respectively. The median time to postetomidate sedation was 10 and 13.5 minutes for succinylcholine and rocuronium patients, respectively.

This retrospective cohort study compared the time to the first sedative in patients intubated with etomidate and succinylcholine versus etomidate and rocuronium.

January 18, 2020

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