This study provides optimized dosing regimens for meropenem and piperacillin/tazobactam in critically ill patients receiving diverse renal replacement therapy (RRT) prescriptions.

Daily dosing is dependent on the target concentration and the main PK determinants in this population, namely RRT intensity, 24-h urine output, and RRT duration in the case of SLED.

As described in the dosing nomogram, extended/continuous infusions facilitate the achievement of optimized antibiotic concentrations in most clinical scenarios, resulting in lower daily doses and a reduced risk of exposure-related toxicity.

300 patients enrolled from 22 intensive care units across 12 countries receiving continuous veno-venous hemodialysis (13.0%), hemofiltration (23.3%), hemodiafiltration (48.4%) or sustained low-efficiency dialysis (15.3%).

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