Severe coronavirus disease 2019 (COVID-19) is associated with immunothrombotic, neutrophil-containing vessel occlusions in the lung, with neutrophils representing the primary immune cell component associated with clinical deterioration, according to study results published in the Journal of Thrombosis and Haemostasis.

The study included 27 patients with COVID-19 who were part of the COVID-19 Registry of LMU University Hospital Munich.

All patients required hospitalization and intensive care treatment.

In addition, the researchers analyzed histologic specimens from 6 patients with COVID-19, 4 patients with H1N1 influenza, and 3 patients with seasonal influenza.

Investigators phenotyped peripheral blood leukocytes in control individuals and patients without COVID-19 pneumonia compared with patients with COVID-19 on normal wards and requiring intensive care treatment.

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