Non-invasive vs. Invasive Respiratory Management Strategies in AHRF Patients

ccforum.biomedcentral.com November 30, 2021

When performing non-invasive ventilation among patients with de novo acute hypoxaemic respiratory failure (AHRF), it is important to avoid excessive tidal volume and lung injury.

Although pressure support is needed for some of these patients, it should be applied with caution because this may lead to excessive tidal volume and lung injury.

We included 25 RCTs (3,302 participants: 27 comparisons). Using SOT as the reference, CPAP was associated significantly with a lower risk of mortality.

Compared with SOT, PSV and HFNO were not associated with a significantly lower risk of mortality.

Compared with IMV, no non-invasive respiratory management was associated with a significantly lower risk of mortality, although all certainties of evidence were very low.