Partial Pressure of Oxygen and Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients

ccforum.biomedcentral.com January 28, 2019

Following out-of-hospital cardiac arrest (OHCA), patients regularly suffer from post cardiac arrest syndrome including symptoms of anoxic brain injury and reperfusion-related damage. Hyperoxemia or hypoxemia exposure occurred in one third of the patients during the first 37 hours of hospitalization and was not significantly associated with poor neurological outcome after 6 months or with the peak s-Tau levels at either 48 or 72 hours after return of spontaneous circulation (ROSC). 869 patients were eligible for analysis. 300 (35%) were exposed to hyperoxemia or hypoxemia at some time point after ROSC. Exploratory post hoc substudy of the Target Temperature Management (TTM) trial, including 939 patients after OHCA with return of spontaneous circulation (ROSC).