Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients

journals.plos.org March 22, 2022

Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia.

A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32) and PAI-1 (POR = 2.96, 95%CI: 1.48 to 6.85) were independently associated with more prominent ED delirium duration in subjects without dementia only.

No significant associations between IL-8, Protein C, sTNRFI, and S100B and ED delirium duration were observed.

We enrolled hospitalized patients who were 65 years or older from the ED. Plasma biomarkers of inflammation, coagulation (Protein C), endothelial activation, and BBB injury (S100B) at were measured using blood obtained at enrollment.

The dependent variable was ED delirium duration which was determined by the Brief Confusion Assessment Method assessed in the ED and hospitalization.

Proportional odds logistic regression analyses were performed adjusted for relevant confounders and allowing for interaction by baseline dementia status.