Thrombocytopenia is common in critically ill patients and is associated with higher bleeding risk and worse outcomes.

Platelet transfusions are frequently used to prevent or treat bleeding, though often with uncertain benefits and potential harms.

1. Platelet concentrates are scarce collective resources.

2. Platelet concentrates undergo storage lesions.

3. Prophylactic platelet transfusion reduces the risk of bleeding.

4. Prophylactic platelet transfusion thresholds are heterogeneous.

5. The dose of prophylactic platelet transfusion does not modulate the risk of bleeding.

6. Post‑transfusion platelet increments are often poor in critically ill patients.

7. Pre‑procedural platelet transfusions: some initial answers.

8. Platelet transfusions improve outcomes inseverely injured bleeding patients.

9. Platelet transfusions are not indicated forthe reversal of anti‑platelet agents.

10. Platelet transfusions harbor potential side effects.

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