PPIs do not increase risk for C. difficile infection in ICU

healio.com October 27, 2018

Proton pump inhibitors are not associated with an increased risk for Clostridium difficile infection in ICU patients, according to the results of a retrospective cohort study. PPI use was not associated with a significant increase in CDI risk among patients who did not receive antibiotics (aHR = 1.56; 95% CI, 0.72-3.35). However, PPI use was actually associated with a lower risk for CDI among patients who did receive antibiotics (aHR = 0.64; 95% CI, 0.48-0.83).