Despite controversy, major health systems across the globe are obtaining and making use of genome sequence data in patients they care for, hoping this approach will prove beneficial.1 Genome sequencing technology, a key driver of precision medicine, has improved substantially in accuracy, speed, and cost. As a consequence, clinicians, health systems, and governments acknowledge that individuals can have their genome sequenced and interpreted for about the cost of commonly used advanced diagnostic imaging tests. This makes obtaining genome sequence data for large numbers of individuals with and without known health issues possible.

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