Rapid Oral Phenytoin Loading in the ED

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rapid-oral-phenytoin-loading-in-the-ed

Oral phenytoin loading can be achieved in a single dose, obviating the need for an IV while still achieving quick administration, adequate serum levels, and minimal side effects. Both the immediate release (suspension or chewable tablet) and extended release (phenytoin sodium ER capsule) products have been used successfully. IV loading does achieve quicker therapeutic level (3 hours), so there may still be a risk of seizure for a short time after oral loading.

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