In 27,395 patients with stable atherosclerotic disease, the addition of 2.5 mg rivaroxaban twice daily to aspirin therapy reduced the rates of cardiovascular death, stroke, or nonfatal MI, at the cost of increased major bleeding rates. The authors found a 1.3% absolute risk reduction in recurrent cardiovascular events, but a 1.2% absolute increase in major bleeding rates, although intracranial and fatal bleeding rates were similar between the two groups.

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