Overall, patients with subsegmental pulmonary embolism who did not have proximal deep venous thrombosis had a higher-than-expected rate of recurrent venous thromboembolism (VTE).

Recruitment was stopped prematurely because the predefined stopping rule was met after 292 of a projected 300 patients were enrolled.

Of the 266 patients included in the primary analysis, the primary outcome occurred in 8 patients, for a cumulative incidence of 3.1% over the 90-day follow-up.

The incidence of recurrent venous thromboembolism was 2.1% and 5.7% over the 90-day follow-up in patients with single and multiple isolated subsegmental pulmonary embolism, respectively.

No patients had a fatal recurrent pulmonary embolism.

The primary outcome was recurrent venous thromboembolism during the 90-day follow-up period.

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