TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients

ccforum.biomedcentral.com April 25, 2019

The proportion of CD127lowPD-1high T cells in patients was increased compared with healthy volunteers, although no global CD127 regulation was observed. Our results suggest that TCR activation participates in the occurrence of this T-cell population and in the development of T-cell alterations in septic shock. Furthermore, we provide an ex vivo model for the investigation of the pathophysiology of sepsis-induced T-cell immunosuppression and the testing of innovative immunostimulant treatments. In patients, neither CD127 expression nor its corresponding mRNA transcript level was modified compared with normal values. CD127 expression was followed at the protein and mRNA levels in patients with septic shock and healthy volunteers.