Patients with a history of COVID-19 pneumonia who present with clinical symptoms such as shock, nausea, vomiting, and fatigue should have hypocortisolism included in the differential diagnosis.

These patients should also be followed over the long term to understand the persistence of adrenal insufficiency and its recovery rate.

Finally, all patients who suffer from long COVID syndrome might benefit from an analysis of hypothalamic–pituitary axis function.

Hypocortisolism, predominantly caused by pituitary disruption, may emerge after SARS-CoV-2 infection and should be considered in patients with a history of COVID-19 pneumonia with or without clinical hypocortisolism.

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