Among critically ill adults, compared to control, low molecular weight heparin (LMWH) reduces incidence of deep venous thrombosis (DVT) while UFH and mechanical compressive devices may reduce risk of DVT.

LMWH is probably more effective than UFH in reducing incidence of DVT, and should be considered the primary pharmacologic agent for thromboprophylaxis.

The efficacy and safety of combination pharmacologic therapy and mechanical compressive devices was unclear.

We included 13 RCTs (9,619 patients).

Compared to control, low molecular weight heparin (LMWH) reduces the incidence of DVT and unfractionated heparin (UFH) may reduce the incidence of DVT.

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