Whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Results from the current study suggest that WBH holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Future studies will be required to identify both the optimal temperature and number and timing of treatments likely to produce the largest and longest-lasting clinical response in most patients.

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