An Optimal Antibiotic Selection Framework for Sepsis Patients Using AI

In this work we present OptAB, the first completely data-driven online-updateable antibiotic selection model based on Artificial Intelligence (AI) for Sepsis patients accounting for side-effects. OptAB performs an iterative... read more

Tags: AI, antibiotics, ICU, infection, sepsis, SOFA, study, technology, treatment,

Sepsis: Clinical Diagnosis and Treatment

Sometimes our body’s reaction to infection can result in damage to internal tissues and organs. Such a condition is referred to as sepsis. Some of the symptoms of sepsis are high fever, increased heart and breathing... read more

Tags: book, diagnosis, infection, sepsis, treatment,

Personalizing Beta-blockade in Septic Shock

Clinical trials provide only part of the necessary framework for clinical decision-making. In practice, a detailed understanding of each patient’s hemodynamic profile is essential. We believe that the echocardiography-guided... read more

Tags: arrhythmia, cytokine, hemodynamics, sepsis, septic shock, tachycardia, trial,

The Beta-Blocker Story: Getting It Right

The idea of using beta-blockers as a treatment for ventricular fibrillation occurred to James Black over 60 years ago. He developed propranolol and cimetidine, among other pharmacologic agents, work for which he won the Nobel... read more

Tags: atrial fibrillation, beta-blockers, book, education, hypertension,

Prediction of Prolonged Mechanical Ventilation in the ICU via Machine Learning

Early recognition of risk factors for prolonged mechanical ventilation (PMV) could allow for early clinical interventions, prevention of secondary complications such as nosocomial infections, and effective triage of hospital... read more

Tags: AI, COVID-19, ICU, intubation, mechanical ventilation, study, technology, ventilation, weaning,

Outcomes of Older Adults With Sepsis at Admission to an ICU

Our study suggests that treating older adults with therapies recommended by the Surviving Sepsis Campaign may improve outcomes in this age group, although mortality remains high for older adults with sepsis. In addition,... read more

Tags: antimicrobial, diagnosis, HAI, ICU, resuscitation, sepsis, study,

The Infectious Disease Diagnosis: A Case Approach

This text uses cases to illustrate differential diagnoses of various infectious diseases. Unlike any other book on the market, this book is specifically designed for ease of use and can cater to a variety of medical professionals... read more

Tags: book, diagnosis, ICU, infection, reference,

AI Interpretation of Chest Radiographs in the ICU. Ready for Prime Time?

Chest radiography (CXR) is the primary tool to visualize thoracic pathologies in the ICU. However, accurate interpretation of CXRs is challenging, even when imaging is performed under optimal conditions. This results in both... read more

Tags: AI, diagnostics, ICU, monitoring, radiography, technology, treatment, ultrasound,

Improving Critical Care Survivorship: A Guide to Prevention, Recovery, and Reintegration

This book, just published, provides a comprehensive overview of improving critical care survivorship. Comprised of four sections, the text presents interventions that can be used to improve patient outcomes and reduce the... read more

Tags: book, education, ICU, recovery, rehabilitation,

Mechanical Ventilation Timing in Sepsis

A recent study by Dr. Kim and colleagues examined the association between the timing of mechanical ventilation (MV) and clinical outcomes in ICU patients with sepsis. The study included 2440 adult sepsis patients from 20... read more

Tags: ARDS, HFNC, ICU, mechanical ventilation, oxygenation, sepsis, study, ventilation,

Lymphocyte Count Trajectories Associated with Prognosis of Sepsis Patients

Three distinct lymphocyte trajectories were identified in sepsis patients using GBTM. Trajectory 3 was a strong predictor of 7-day and 28-day mortality, while Trajectory 1 was associated with early death. These findings might... read more

Tags: immunosuppression, infection, prognosis, sepsis, SIRS, SOFA, steroids, study,

Effect on Norepinephrine Administration Timing on Prognosis of Septic Shock Patients

Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-h intravenous... read more

Tags: antibiotics, ICU, infection, LOS, norepinephrine, prognosis, sepsis, septic shock, study, treatment,

Personalized Therapies in ARDS

Acute respiratory distress syndrome (ARDS) can result from a variety of clinical conditions, causing lung injury either directly through local inflammation or indirectly because of systemic inflammatory mediators ARDS is... read more

Tags: ARDS, ICU, inflammation, pneumonia, research, sepsis, therapy, treatment,

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

Tags: AKI, ICU, nutrition, resuscitation, SOFA, treatment, vasopressors,

Optimizing ICU Weaning: Globalizing Personalized Weaning Strategies

this study provides compelling evidence supporting the concept of individualized weaning in the ICU. By tailoring spontaneous breathing trial (SBT) methods to match specific patient conditions, it represents an essential... read more

Tags: diabetes, hypertension, ICU, rehabilitation, SBT, trial, weaning,

Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment

Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing... read more

Tags: book, education, hypothermia, ICU, nephrology, treatment,

Heart Rate Control in Septic Shock: Echocardiographic Evaluation and Monitoring

Our study demonstrated a modest reduction in heart rate by approximately 10 beats per minute, accompanied by a slower decrease in noradrenaline requirements com-pared to the control group in the overall population. This observation... read more

Tags: echocardiography, monitoring, sepsis, septic shock,

Unaccountable: What Hospitals Won’t Tell You and How Transparency Can Revolutionize Health Care

Dr. Marty Makary is co-developer of the life-saving checklist outlined in Atul Gawande’s bestseller The Checklist Manifesto. A Johns Hopkins surgeon and professor of public health, he can testify to the amazing power...

Neurocritical Care Board Review: Questions and Answers, Second Edition – Comprehensive Neurocritical Care Review Book with 740 Practice Questions, Includes Digital eBook Access

Updated and expanded, the second edition of Neurocritical Care Board Review contains multiple-choice questions that cover the breadth of topics tested on the neurocritical care boards with answers and rationales for self-study....