Occasionally heart wrenching and always fast-paced, Miracles and Mayhem in the ER will have readers holding their breath one second and celebrating the next. Through his night shifts at a renowned Portland,... read more

Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co‑adjuvant therapy. A total of 1846... read more

Recent medical history has largely viewed our bacterial symbionts as pathogens to be eradicated rather than essential partners in optimal health. However, one of the most exciting scientific advances in... read more

A devastating and utterly original analysis of what has gone wrong with the American healthcare system. Goldhill explodes the myth that Medicare and insurance coverage can make care cheaper and improve... read more

Synchrony between the patient and the ventilator is defined as the appropriate interaction between the two, where the ventilator recognizes patient’s effort and provides support for breathing at the... read more

A medical watchdog group is calling on the National Institutes of Health to immediately stop the enrollment of patients in a clinical trial of sepsis treatment and launch an investigation of how the study... read more

Sharpen your critical care skills, with the fully updated Quick Reference to Critical Care, fifth 5th edition. This well-illustrated pocket guide covers the full range of critical care scenarios, listing... read more

The findings of this study suggest that the ΔIVCD performed moderately well in predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation. Overall, 603 patients... read more

Sepsis is deadly, it’s expensive, and there are abundant initiatives underway that could lead to earlier detection, lowering costs, and saving lives. In May 2016, the Healthcare Cost and Utilization... read more

In THE DANGER WITHIN US, award-winning journalist Jeanne Lenzer brings these horrifying statistics to life through the story of one working class man who, after his “cure” nearly kills him,... read more

Clostridium difficile infection (CDI) is less common than antibiotic-associated diarrhea and irritable bowel syndrome. There is significant concern about overdiagnosis and subsequent overtreatment of CDI... read more

Mr. Jackson is a 36-year-old man whom you are caring for in the intensive care unit (ICU). Before this hospitalization, he was healthy and took no medications. He has never smoked, and he drinks three... read more

Aminophylline administration provided a measure of increased diuresis, regardless of dosage, and theophylline trough levels. Therefore, achieving a prescribed therapeutic trough level may not be necessary... read more

Among patients with severe secondary mitral regurgitation, the rate of death or unplanned hospitalization for heart failure at 1 year did not differ significantly between patients who underwent percutaneous... read more

Urinary L-FABP and serum NT-proBNP levels on admission are independent predictors of acute kidney injury (AKI), and when used in combination, improve early prediction of AKI in patients hospitalized at... read more

Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived... read more

Over the past decade, salaries for hospital CEOs have risen much faster than for surgeons, physicians, and nurses, reports a study in Clinical Orthopaedics and Related Research. Using publicly accessible... read more

The administration of a continuous infusion of hydrocortisone to a general population of patients in septic shock on mechanical ventilation cannot be recommended at this time. The authors conclusion that... read more

Dr Kimberley Haines, Vice Chair of ANZICS Victorian Branch and ICU Physio at Western Health joins Dan and Jane to discuss survival following ICU admissions.Dr Kimberley discusses her journey to research,... read more

Early initiation of renal replacement therapy (RRT) effect on survival and renal recovery of critically ill patients is still uncertain. We aimed to systematically review current evidence comparing outcomes... read more