Gene could lead to ALS therapies
Researchers from Ben-Gurion University of the Negev say their new gene study could lead to new treatments for amyotrophic lateral sclerosis, or ALS.... read more
Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials
Network meta-analysis showed no mortality benefit of tight glycemic control in critically ill patients, but fivefold more hypoglycemia versus mild or very mild control.... read more
Urine test may detect Creutzfeldt-Jakob disease
Researchers at the Medical Research Council in Britain have discovered it may be possible to test patients for Creutzfeldt-Jakob disease using urine samples.... read more
Should we treat pyrexia? And how do we do it?
Pyrexia has long been thought of as a protective physiological response to help host defences, although this is now being challenged. Despite recent advances, it remains unclear whether pyrexia or the physiological response... read more
Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation
In recent years there have been many developments in post-resuscitation care. We have investigated trends in patient characteristics and outcome following admission to UK critical care units following cardiopulmonary resuscitation... read more
Association of Sodium Selenite and Procalcitonin-Guided Therapy With Mortality
This randomized clinical trial evaluates the use of high-dose sodium selenite, with or without use of a procalcitonin algorithm to guide therapy, and its association with mortality in patients with severe sepsis.... read more
Dysbiosis Across Multiple Body Sites in Critically Ill Adult Surgical Patients
Current evidence suggests that symbiosis of commensal microflora play a significant role in health and illness. The effect that commensal microflora play in critical care is less well known.... read more
Smoking, vitamin D deficiency linked to early MS disability
Severe vitamin D deficiency and current smoking predicted accumulated disability in patients with clinically isolated syndrome, which can be a precursor to the development of multiple sclerosis.... read more
Gene therapy for LPLD patients linked to lower frequency and severity of pancreatitis
Up to 6 years after receiving a single treatment with the gene therapy product lipoprotein lipase (LPL), patients with the debilitating genetic disease LPL deficiency (LPLD) had about 50% fewer episodes of pancreatitis than... read more
ICDs appear not to improve overall survival in non-ischemic systolic HF
This paper reports the findings of the DANISH study, a multicenter, unblinded, randomized, controlled trial to compare outcomes in patients with non-ischemic systolic heart failure who received cardiac resynchronization therapy... read more
HDAC inhibitors show promise against cancer stem cells
A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate... read more
Newer blood thinning drugs safer for reducing atrial fibrillation
Although warfarin has been used for nearly 60 years, researchers say newer blood thinners are a better option for lowering stroke risk among atrial fibrillation patients because they work for a shorter time with fewer side... read more
VTE history in female relatives increases absolute thrombotic risk
A family history of thrombosis in women may increase the risk for venous thromboembolism in women taking oral contraceptives, according to the results of a cohort study.... read more
Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke
Compared to patients treated with medical therapy alone, patients with an ischemic stroke undergoing endovascular thrombectomy combined with medical therapy had lower rates of disability 3 months after their stroke.... read more
Beta-Lactam Infusion in Severe Sepsis (BLISS)
Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.... read more
What goes into the first aid kit of the future?
A revolution is taking place in the recesses of bathroom mirrors and pantry cabinets as a new wave of gadgets expand our conception of the First Aid Kit.... read more
FDA approves automated insulin delivery device for type 1 diabetes
The Food and Drug Administration (FDA) has approved a device that automatically monitors blood glucose levels and delivers insulin when appropriate, for people aged 14 years and older who have type 1 diabetes.... read more
