Mechanical Power: Meaning, Uses and Limitations

Mechanical Power: Meaning, Uses and Limitations

Ventilator-induced lung injury (VILI) carries significant attributable mortality in acute respiratory distress syndrome (ARDS). Even though all the ventilatory variables contribute to VILI, current guidelines focus almost... read more

Cardiovascular Mortality Post Burn Injury

Cardiovascular Mortality Post Burn Injury

Survivors from burn injury, especially young males, are at increased long-term risk of death from cardiovascular disease. Increased screening and counseling pertaining to lifestyle factors should be standard management post-burn... read more

Dexmedetomidine, Almost As Many Uses As There Are Letters

Dexmedetomidine, Almost As Many Uses As There Are Letters

There is literature to support the use of dexmedetomidine in patients with sympathomimetic toxidrome. It may be a reasonable approach to utilize Dex, with or without a bolus, while closely monitoring these patients in an... read more

Postoperative Pulmonary Complications in the ENIGMA II Trial

Postoperative Pulmonary Complications in the ENIGMA II Trial

Respiratory complications remain among the most common and serious adverse outcomes of major surgery. In the Australian and New Zealand Audit of Surgical Mortality, postoperative pneumonia accounted for 44% of infective... read more

COVID-19 Treatment Guidelines New Version Published

COVID-19 Treatment Guidelines New Version Published

The COVID-19 Treatment Guidelines Panel (the Panel) is pleased to announce the publication of an updated version of the Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In the United States, the prevalence of... read more

Intensive Care in Nephrology

Intensive Care in Nephrology

The field of intensive care in nephrology is a rapidly evolving one, with research starting to translate into clinical guidelines and standards. Encompassing core subjects in critical care and nephrology, as well as specific... read more

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

Interim Clinical Treatment Considerations for Severe Manifestations of Mpox

The Centers for Disease Control and Prevention (CDC) released a Morbidity and Mortality Weekly Report (MMWR) titled "Interim Clinical Treatment Considerations for Severe Manifestations of Mpox—United States, February 2023."... read more

Sick Children Identification in Acute Care Settings

Sick Children Identification in Acute Care Settings

At the heart of every pediatric consultation is the clinician’s responsibility to determine ‘is this child sick?’ In pediatrics illustrative language communicates a clinical picture of the child before us. When... read more

Loved Ones Are Not “Visitors” in a Patient’s Life

Loved Ones Are Not “Visitors” in a Patient’s Life

Hospitals are institutions whose primary task is to treat patients. Family-centered care, which considers loved ones as equal partners in patient care, has been gaining recognition in the adult care setting. Our aim was... read more

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Bempedoic Acid Associated with Lower Risk of Cardiovascular Events

Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or... read more

The CLOVERS Trial: Does Nothing Matter in Sepsis?

The CLOVERS Trial: Does Nothing Matter in Sepsis?

The CLOVERS trials is an open label RCT that did not demonstrate any difference (beneficial or harmful) from using a restrictive fluid strategy over a liberal fluid strategy in sepsis-induced hypotension. Do whatever... read more

Delirium Prevention in the ICU: Melatonin or Ramelteon

Delirium Prevention in the ICU: Melatonin or Ramelteon

Melatonin modulates the circadian rhythm and has been studied as a preventive measure against the development of delirium in hospitalized patients. Such an effect may be more evident in patients admitted to the ICU, but findings... read more

Early Identification of Intra-abdominal Infection and Sepsis

Early Identification of Intra-abdominal Infection and Sepsis

This case report illustrates the ability of the novel biomarker pancreatic stone protein (PSP) concentrations to act as a warning sign, allowing the early identification of intra-abdominal infection and post-operative peritonitis... read more

Higher Protein Dosing in Critically Ill Patients with High Nutritional Risk

Higher Protein Dosing in Critically Ill Patients with High Nutritional Risk

Delivery of higher doses of protein to mechanically ventilated critically ill patients did not improve the time-to-discharge-alive from hospital and might have worsened outcomes for patients with acute kidney injury (AKI)... read more