Sevoflurane in Murine Peritonitis-induced Sepsis

Sevoflurane in Murine Peritonitis-induced Sepsis

Sevoflurane exerts various protective effects in two murine peritonitis-induced sepsis models. These protective effects were linked with a functional adenosine A2B receptor. Sevoflurane reduced the neutrophil counts in... read more

Oral Midodrine Feasibility in Early Sepsis

Oral Midodrine Feasibility in Early Sepsis

This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

Sabah in Malaysian Borneo is among the Malaysian states which reported a high number of detected COVID-19 cases during the current pandemic. Due to geographical challenges and limited resources, clinicians developed novel... read more

Increasing the Reproducibility of Research Reduces the Problem of Apophenia

Increasing the Reproducibility of Research Reduces the Problem of Apophenia

Apophenia, or the tendency of identifying meaningful patterns where none truly exist, is part of the human condition. We cannot surmount it, but we can strive to manage its influence. In the research context, apophenia can... read more

COVID-19: Convalescent Plasma vs. Standard Plasma

COVID-19: Convalescent Plasma vs. Standard Plasma

Administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome. Enrollment... read more

Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes

Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes

This study suggests that β-blocker exposure prior to sepsis, especially to noncardioselective β blockers, may be associated with better outcome. The findings suggest prospective evaluation of β-blocker use in the management... read more

Guidance on COVID-19 Clinical Care and Treatment by Specialty

Guidance on COVID-19 Clinical Care and Treatment by Specialty

We are providing these links as part of our support to members seeking specialty advice for specific medical conditions, particularly those outside their own specialty. The situation is a fast-evolving one, and while we will... read more

Undercover Epicenter Nurse: How Fraud, Negligence, and Greed Led to Unnecessary Deaths at Elmhurst Hospital

Undercover Epicenter Nurse: How Fraud, Negligence, and Greed Led to Unnecessary Deaths at Elmhurst Hospital

What would you do if you discovered that the media and the government were lying to us all? And that hundreds, maybe thousands of people were dying because of it? Army combat veteran and registered nurse Erin Olszewski’s... read more

Bodily Pain in Survivors of ARDS

Bodily Pain in Survivors of ARDS

Nearly half of acute respiratory distress syndrome (ARDS) survivors reported bodily pain at 6- and 12-month follow-up; one-third reported pain at both time points. Pre-ARDS unemployment, smoking history, and in-ICU opioid... read more

New Therapy Could Protect Lung Function in COVID-19 Patients

New Therapy Could Protect Lung Function in COVID-19 Patients

There is an urgent need for new drugs for ARDS patients, including those with COVID-19. ARDS in influenza-infected mice is associated with reduced levels of liponucleotides (essential precursors for de novo phospholipid synthesis)... read more

Persistent Neuropsychiatric Symptoms After COVID-19

Persistent Neuropsychiatric Symptoms After COVID-19

The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of... read more

Trend and Pattern of 100 ARDS Patients Teferred for VV ECMO Treatment

Trend and Pattern of 100 ARDS Patients Teferred for VV ECMO Treatment

Referral to specialized center for venovenous (VV) ECMO treatment should be considered expeditiously in case of refractory ARDS, which is often lethal. Transport of unstable patients, although challenging, is feasible and... read more

Ultrasound Grayscale Analysis in ARDS COVID-19

Ultrasound Grayscale Analysis in ARDS COVID-19

Recent evidence regarding the novel coronavirus disease 2019 (COVID19) is growing in describing the characteristics of this disease, with main focus on lung morphology. Few data are available regarding the peripheral and... read more

Promoting Evidence-Based Practice in ARDS

Promoting Evidence-Based Practice in ARDS

There is a dearth of literature addressing interventions to improve implementation of evidence-based practices in acute respiratory distress syndrome (ARDS). Existing interventions to improve clinician knowledge and facilitate... read more

Mythbusting: (Empty IVC + Hyperkinetic Heart) Does Not Equal Volume Depletion

Mythbusting: (Empty IVC + Hyperkinetic Heart) Does Not Equal Volume Depletion

An empty IVC and hyperkinetic heart does not equal volume depletion. This combination of echocardiographic findings may result from either vasodilatory shock (as illustrated above) or hypovolemic shock. If encountered in... read more

Remestemcel-L reduces ARDS mortality in those under 65 years old

Remestemcel-L reduces ARDS mortality in those under 65 years old

New data shows patients with COVID-19-related Acute Respiratory Distress Syndrome (ARDS) were up to 75 percent less likely to die when treated with remestemcel-L and dexamethasone. The data shows remestemcel-L reduced... read more

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

In a retrospective analysis of consecutive intubated subjects with moderate or severe ARDS, related or not to COVID-19, spontaneous breathing during prone positioning (PP) was well tolerated and achieved significant improvement... read more