Stories Category: Intensive Care
Galectin-3 in Septic AKI
This translational study demonstrates the importance of Gal-3 in the pathogenesis of sepsis acute kidney injury (S-AKI), and its potential utility as a therapeutic target. In 57 patients admitted to the intensive care... read more
Increased risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1
We started estimating the SARS-CoV-2 reproduction number in the UK using Public Health England data in March 2020, contributing to the Scientific Pandemic Influenza Modelling subgroup (SPI-M) weekly consensus estimates. In... read more
The Influence of Airflow Via High-Flow Nasal Cannula on Duration of Laryngeal Vestibule Closure
The purpose of this experimental study was to investigate the influence of airflow via high-flow nasal cannula (HFNC) on the duration of laryngeal vestibule closure (dLVC) and Penetration-Aspiration Scale (PAS) scores. 29... read more
Traumatic and Ischemic Injury: Methods and Protocols
This volume focuses on procedures for the development and application of several research animal models and in vitro methods that allow researchers to gain insight into the underlying cellular, biochemical, and physiological... read more
Outcomes and Risk Factors Associated with COVID-19 Infection of Patients with Multiple Sclerosis
In this registry-based cross-sectional study, increased disability was independently associated with worse clinical severity including death from COVID-19. Other risk factors for worse outcomes included older age, Black race,... read more
When I Use a Word… Homeostasis and Allostasis
In most cases we do not know who first coined or even used a word. Evidence can generally be found of the earliest instance of a word in written texts, but we do not have a written history of speech nor vocal recordings earlier... read more
Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU
Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome... read more
Functional Hemodynamic Monitoring With a Wireless Ultrasound Patch
In this Emerging Technology Review, a novel, wireless, wearable Doppler ultrasound patch is described as a tool for resuscitation. The device is designed, foremost, as a functional hemodynamic monitor-a simple, fast, and... read more
Common Problems in the ICU
A concise learning tool designed for residents, nurses, and other ICU professionals, Textbook of Critical Care: Common Problems in the ICU highlights the most common conditions encountered in the ICU – all in a convenient... read more
Left Septal Fascicular Block
This book provides clinical and electrovectorcardiographic evidence of the existence of left septal fascicular blocks and demonstrates the clinical importance of these blocks in the clinical scenario of acute coronary syndrome.... read more
Timing of Intubation in Patients With COVID-19
The timing of intubation in hypoxemic patients with COVID-19 has been hotly debated. Early in the pandemic, there was a push to intubate early, driven by the effort to reduce transmission of the virus. With time, high-flow... read more
Cardiorespiratory Compromise in the Perioperative Environment
Perioperative cardiorespiratory compromise is common and goes largely undetected. Predictive cardiorespiratory indices can help in early detection of harmful deviations and guide preemptive treatment. Using continuous... read more
A Systematic Review of Indoor Air Sampling for COVID-19 Detection
In a post-pandemic scenario, indoor air monitoring may be required seeking to safeguard public health, and therefore well-defined methods, protocols, and equipment play an important role. Considering the COVID-19 pandemic,... read more
Long-Term Survival Following Sepsis
The nearly 75% mortality four years after diagnosis indicates that changes are needed both in the acute treatment of patients with sepsis and in their multi-sector long-term care. The applicability of these findings may be... read more
Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation
In this pilot study, we demonstrated the feasibility of ∆TOI as a dynamic value rather than single static value among OHCA patients in a pre-hospital setting. ∆TOI can be considered as a predictor of return of spontaneous... read more
Apremilast Not Likely to Reduce Time to Recovery or Mortality in Critically Ill Patients in I-SPY COVID-19 Trial
Quantum Leap Healthcare Collaborative (QLHC), the sponsor of the I-SPY COVID Trial, announced that apremilast (Otezla), made by Amgen, has been dropped for futility. Apremilast was chosen for testing in the I-SPY COVID Trial... read more
The Bougie as an Airway Savior
Ever since the BEAM (Bougie Use in Emergency Airway Management) trial was published in JAMA in 2018, the use of the bougie has become increasingly mainstream. Some of the advantages of using a bougie are known, but there... read more
