Identifying Barriers to Nurse-Facilitated Patient Mobility in the ICU

Identifying Barriers to Nurse-Facilitated Patient Mobility in the ICU

Nurses have limited time for additional clinical activities but may miss potentially important opportunities for facilitating patient mobility during existing patient care. The proposed method is feasible and helpful in empirically... read more

Age- and Gender-related Peculiarities of Patients with Delirium in the Cardiac ICU

Age- and Gender-related Peculiarities of Patients with Delirium in the Cardiac ICU

Our investigation presented a number of associated peculiarities related to gender and age. It was shown that delirium is a severe complication that more often affects men amongst patients < 65 years old and more frequently... read more

Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant Klebsiella Pneumoniae and Escherichia Coli

Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant Klebsiella Pneumoniae and Escherichia Coli

Tigecycline monotherapy was a choice if the strains exhibited MIC ≤0.5 mg/L, and colistin monotherapy was not suitable. Our findings can initiate additional clinical studies regarding the efficacy of tigecycline in carbapenem-resistant... read more

Antibiotic timing in Severe Sepsis

Antibiotic timing in Severe Sepsis

Severe sepsis is a time dependent condition and this study builds on previous literature which supports that early identification and treatment of sepsis with antibiotics decreases mortality. Retrospective analysis of a large... read more

Probiotic and Synbiotic Therapy in Critical Illness

Probiotic and Synbiotic Therapy in Critical Illness

Critical illness is characterized by a loss of commensal flora and an overgrowth of potentially pathogenic bacteria, leading to a high susceptibility to nosocomial infections. Probiotics are living non-pathogenic microorganisms,... read more

Partial Pressure of Oxygen and Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients

Partial Pressure of Oxygen and Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients

Following out-of-hospital cardiac arrest (OHCA), patients regularly suffer from post cardiac arrest syndrome including symptoms of anoxic brain injury and reperfusion-related damage. Hyperoxemia or hypoxemia exposure occurred... read more

Adherence to Guidelines for the Management of Donors After Brain Death

Adherence to Guidelines for the Management of Donors After Brain Death

Guideline adherence to an expert panel predefined care set in brain death (DBD) donor management proved moderate leaving substantial room for improvement. An importance-performance analysis can be used to improve implementation... read more

Surfactant protein D is a causal risk factor for COPD

Surfactant protein D is a causal risk factor for COPD

Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive... read more

Predicting the Haemodynamic Response to Prone Positioning

Predicting the Haemodynamic Response to Prone Positioning

A Novel and Simultaneous Analysis of the Guyton and Rahn Diagrams. Graphical models of physiology are heuristically appealing as they facilitate qualitative conclusions at the bedside of the critically ill. Historically,... read more

Risk Factors for 1-Year Mortality and Hospital Utilization Patterns in Critical Care Survivors

Risk Factors for 1-Year Mortality and Hospital Utilization Patterns in Critical Care Survivors

One in five ICU survivors die within 1 year, with advanced age and comorbidity being significant predictors of outcome, leading to high resource use. Care process factors indicating high system stress were associated with... read more

Epidemiology of Mechanically Ventilated Patients Treated in ICU and non-ICU Settings in Japan

Epidemiology of Mechanically Ventilated Patients Treated in ICU and non-ICU Settings in Japan

A large proportion of Japanese patients on mechanical ventilation (MV) were treated in non-ICU settings. Analysis of administrative data indicated preliminary that hospital mortality rates in these patients were higher in... read more

Association of Driving Pressure With Mortality Among Ventilated Patients With ARDS

Association of Driving Pressure With Mortality Among Ventilated Patients With ARDS

Our study confirmed an association between higher driving pressure and higher mortality in mechanically ventilated patients with acute respiratory distress syndrome (ARDS). These findings suggest a possible range of driving... read more

The Effectiveness of Non-Pharmacological Interventions in Reducing the Incidence and Duration of Delirium in Critically Ill Patients

The Effectiveness of Non-Pharmacological Interventions in Reducing the Incidence and Duration of Delirium in Critically Ill Patients

Current evidence does not support the use of non-pharmacological interventions in reducing incidence and duration of delirium in critically ill patients. Future research should consider well-designed and well-described multicomponent... read more

Cost-effectiveness of Procalcitonin Testing to Guide Antibiotic Treatment Duration in Critically Ill Patients

Cost-effectiveness of Procalcitonin Testing to Guide Antibiotic Treatment Duration in Critically Ill Patients

Although the impact of PCT guidance on total healthcare-related costs during the initial hospitalisation episode is likely negligible, the lower in-hospital mortality may lead to a non-significant increase in costs over a... read more