Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more

The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

COVID-19 related cardiopulmonary failure such as ARDS and cardiogenic shock or massive pulmonary embolism can be successfully supported with ECMO. Judicious patient selection is important to enable maximal benefit and optimized... read more

Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19

Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19

Patients with coronavirus disease 2019 (COVID-19) can develop acute respiratory distress syndrome (ARDS), which has been linked to poor prognosis and is a major contributor to patient death. A better understanding of the... read more

Inhaled Pulmonary Vasodilators

Inhaled Pulmonary Vasodilators

Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more

30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath

30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath

The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic... read more

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more

Critical Care and Hospitalist Medicine Made Ridiculously Simple

Critical Care and Hospitalist Medicine Made Ridiculously Simple

A fundamental and thorough guide to the treatment of hospitalized patients in critical care situations, "Critical Care and Hospitalist Medicine Made Ridiculously Simple" provides both introductory information as well as a... read more

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

During the coronavirus disease (COVID-19) global pandemic, urgent strategies to alleviate shortages are required. Evaluation of the feasibility, practicality, and value of drug conservation strategies and therapeutic alternatives... read more

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Approximately two-thirds of patients admitted to the intensive care unit (ICU) for coronavirus disease-19 (COVID-19) pneumonia present with the acute respiratory distress syndrome (ARDS). COVID-19-associated acute cardiac... read more

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19

Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... read more

Perhaps something isn’t always better than nothing

Perhaps something isn’t always better than nothing

It is not unreasonable to say the COVID-19 pandemic caught most of us by surprise. We did not know how infectious the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus leading to COVID-19 disease was, nor... read more

Spotting the Clotting: Hypercoagulopathy in COVID-19

Spotting the Clotting: Hypercoagulopathy in COVID-19

Evolving experience with TEG, clotting parameters, treatment considerations, and ongoing data gathering will help us better understand if antiplatelet therapy with aspirin or clopidogrel or anticoagulant treatment with traditional... read more

ACEI/ARB Use and Testing Positive for COVID-19

ACEI/ARB Use and Testing Positive for COVID-19

This retrospective cohort study reports that taking either an angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) was not associated with an increase in the likelihood of testing positive... read more

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic... read more

Tube Thoracostomy during the COVID-19 Pandemic

Tube Thoracostomy during the COVID-19 Pandemic

This document provides guidance for trauma and acute care surgeons surrounding the placement, management and removal of chest tubes during the COVID-19 pandemic. Tube thoracostomy for a traumatic hemothorax or pneumothorax... read more