Plasma Transfusion Shows Promise for COVID-19 Treatment

Donor blood plasma from people who have recovered from COVID-19 appears to work as a treatment for the virus, a new analysis has revealed. In this preliminary uncontrolled case series of 5 critically ill patients with... read more

Plasma Transfusion Shows Promise for COVID-19 Treatment

Clinical Utility and Technique for Lung Ultrasound in COVID-19 Cases

Since the outbreak of a novel coronavirus in Wuhan in December 2019 and its subsequent evolution to a pandemic in March 2020, there has been growing interest in the utility of lung ultrasound in the workup and management... read more

Clinical Utility and Technique for Lung Ultrasound in COVID-19 Cases

Focus on Clinical Trial Interpretation

In a recently published meta-epidemiological study of 604 randomised clinical trials (RCTs) published between 1977 and 2018 from 53 Cochrane systematic reviews in critical care, less than 7% of the RCTs had overall low risk... read more

Focus on Clinical Trial Interpretation

Lung Ultrasonography Features of COVID-19 Pneumonia

As lung abnormalities may develop before clinical manifestations and nucleic acid detection, experts have recommended early chest computerized tomography (CT) for screening suspected patients. The high contagiousness... read more

Lung Ultrasonography Features of COVID-19 Pneumonia

WHO Declares the Coronavirus Outbreak a Pandemic

The World Health Organization on Wednesday declared the rapidly spreading coronavirus outbreak a pandemic, acknowledging what has seemed clear for some time — the virus will likely spread to all countries on the globe. Director-General... read more

ARDS Diagnosis May Be Underrecognized

The February 27, 2020 Department of Internal Medicine Medical Grand Rounds "Acute Respiratory Distress Syndrome (ARDS),” was presented by Marc Moss, MD, Roger S. Mitchell Professor of Medicine; head, Division of Pulmonary... read more

ARDS Diagnosis May Be Underrecognized

Instrumental Activities of Daily Living Related to ARDS Survivors’ Quality of Life

Instrumental Activities of Daily Living (IADL), not body functions & structures measures, are related to ARDS survivors' quality of life and should be included in future studies. Bringing greater consistency to outcomes... read more

Instrumental Activities of Daily Living Related to ARDS Survivors’ Quality of Life

Respiratory Support for Patients with COVID-19 Infection

Coronavirus disease 2019 (COVID-19) has affected more than 50 countries so far this year. Xiaobo Yang and colleagues described in their single-centered, retrospective, observational study that 52 of 710 patients with confirmed... read more

Respiratory Support for Patients with COVID-19 Infection

Flow-controlled Ventilation Enhances Lung Aeration

Lung-protective ventilation for acute respiratory distress syndrome (ARDS) aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. This study... read more

Flow-controlled Ventilation Enhances Lung Aeration

Validation of Neuromuscular Blocking Agent Use in ARDS

The use of Neuromuscular Blocking Agents (NMBA) could significantly decrease mortality in moderate-to-severe acute respiratory distress syndrome (ARDS) patients and decrease the incidence of barotrauma during mechanical ventilation.... read more

Validation of Neuromuscular Blocking Agent Use in ARDS

Review of the Current Evidence on COVID-19 in Intensive Care

Join Dr. David Lyness as he discusses the current evidence on COVID-19 in Intensive Care. A coronavirus is one of many viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract... read more

Review of the Current Evidence on COVID-19 in Intensive Care

Imaging Changes of Severe COVID-19 Pneumonia in Advanced Stage

The imaging changes of acute stage from a case of 75-year-old male patient with severe COVID-19 pneumonia combined acute respiratory distress syndrome (ARDS), septic shock, and multiple organ dysfunction syndrome (MODS) who... read more

Imaging Changes of Severe COVID-19 Pneumonia in Advanced Stage

Respiratory Drive in the ARDS: Pathophysiology, Monitoring, and Therapeutic Interventions

Neural respiratory drive, i.e., the activity of respiratory centres controlling breathing, is an overlooked physiologic variable which affects the pathophysiology and the clinical outcome of acute respiratory distress syndrome... read more

Respiratory Drive in the ARDS: Pathophysiology, Monitoring, and Therapeutic Interventions

Ventilatory Support and Mechanical Properties of the Fibrotic Lung Acting as a “Squishy Ball”

The management of the patient with lung fibrosis in the ICU is a challenge for the intensivist. The lack of studies defining the mechanical ventilation strategy, and the different underlying etiologies, make it difficult... read more

Ventilatory Support and Mechanical Properties of the Fibrotic Lung Acting as a “Squishy Ball”

WHO Guidelines Regarding Fluid Administration for Coronarvirus Are Dangerously Misguided

Portions of the current WHO guidelines regarding fluid management are dangerously misguided. The first two recommendations suggest limiting fluid administration in patients with ARDS and patients who aren't shocked, to... read more

WHO Guidelines Regarding Fluid Administration for Coronarvirus Are Dangerously Misguided

Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO

Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more

Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO

Clinical Features of Patients Infected with Coronavirus in Wuhan, China

A cohort of 41 patients with laboratory-confirmed 2019-nCoV infection. Patients had serious, sometimes fatal, pneumonia and were admitted to the designated hospital in Wuhan, China, by Jan 2, 2020. Clinical presentations... read more

Clinical Features of Patients Infected with Coronavirus in Wuhan, China

Clinical Decision Support Systems: Future or Present in ICU?

Clinical decision support systems (CDSS) are today, a reality. More complex, useful systems will be developed in the near future, forging CDSS an essential part of ICU monitoring. However, we need to understand the algorithms... read more

Clinical Decision Support Systems: Future or Present in ICU?