The Association Between Ventilator Dyssynchrony, Delivered Tidal Volume, and Sedation Using a Novel Automated Ventilator Dyssynchrony Detection Algorithm

The Association Between Ventilator Dyssynchrony, Delivered Tidal Volume, and Sedation Using a Novel Automated Ventilator Dyssynchrony Detection Algorithm

We developed a computerized algorithm that accurately detects three types of ventilator dyssynchrony. Double-triggered and flow-limited breaths are associated with the frequent delivery of tidal volumes of greater than... read more

Machine Learning for Patient Risk Stratification for ARDS

Machine Learning for Patient Risk Stratification for ARDS

An acute respiratory distress syndrome (ARDS) prediction model based on electronic health record (EHR) data with good discriminative performance has been developed. The results demonstrate the feasibility of a machine... read more

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Pediatric acute respiratory distress syndrome (ARDS) contributes to a significant burden in the PICU of a developing country and is associated with significantly higher mortality. Infection remains the most common etiology.... read more

Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies

Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies

ALI/acute respiratory distress syndrome (ARDS) is characterized by diffuse alveolar damage, alveolar capillary leakage, lung edema, neutrophil-derived inflammation, and surfactant dysfunction. These changes lead to clinical... read more

In-line Filtration of Intravenous Infusion May Reduce Organ Dysfunction of Adult Critical Patients

In-line Filtration of Intravenous Infusion May Reduce Organ Dysfunction of Adult Critical Patients

In-line filtration with finer 0.2 and 1.2 μm filters may be associated with less organ dysfunction and less inflammation in critically ill adult patients. Comparing fine filter vs control filter cohort, respiratory... read more

Adaptive Mechanical Ventilation with Automated Minimization of Mechanical Power

Adaptive Mechanical Ventilation with Automated Minimization of Mechanical Power

Adaptive mechanical ventilation with automated minimization of inspiratory power may lead to more lung-protective ventilator settings when compared with adaptive mechanical ventilation according to Otis' equation. Comparing... read more

Practical Trends in Anesthesia and Intensive Care 2018

Practical Trends in Anesthesia and Intensive Care 2018

This book offers an essential guide to managing the most-debated hot topics of practical interest in anesthesia and intensive care. It reviews the state of the art in issues concerning both intensive care medicine and anesthesia,... read more

Long-term Cognitive Impairment After ARDS

Long-term Cognitive Impairment After ARDS

Reducing the practical burden of cognitive recovery following critical illness depends crucially on understanding the links between brain injury and lung injury. New deficits in learning and memory, and new development... read more

Population Enrichment for Critical Care Trials

Population Enrichment for Critical Care Trials

Enrichment reduces heterogeneity and will enhance the sensitivity of future trials. However, enrichment, even when it identifies more homogenous populations, may not be efficient to deploy in trials or clinical practice. Many... read more

Transport of a Prone Position ARDS Patient

Transport of a Prone Position ARDS Patient

Critical care transport of prone acute respiratory distress syndrome (ARDS) patients is a feasible and cost-effective intervention that will help prevent treatment delays and interruptions. A nonphysician critical care... read more

Vitamin C for Sepsis

Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just... read more

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

TEE accurately predicts invasive PAOP ≤ 18 mmHg in ventilated patients. This further increases its diagnostic value in patients with suspected acute lung injury/acute respiratory distress syndrome. During two consecutive... read more

Circulating Gasdermin-D in Critically Ill Patients

Circulating Gasdermin-D in Critically Ill Patients

This is the first study to demonstrate that the active form of GSDM-D is found exclusively in the circulation of septic critically ill patients raising its potential as an agent of dysregulated immunity in systemic infection.... read more

Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS

Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS

In this preliminary study of patients with sepsis and Acute Respiratory Distress Syndrome (ARDS), a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers... read more