Tag: ARDS
Treating Acid–Base Abnormalities in the ICU
Acidemia has both harmful and beneficial biological effects. Sodium bicarbonate is generally ineffective in raising pH when ventilation is limited, as in patients with ARDS. Even when alkalinizing agents can correct the pH,... read more
Optimal Approach to Mechanical Ventilation After Cardiac Arrest
Return of spontaneous circulation after cardiac arrest results in a systemic inflammatory state called the post-cardiac arrest syndrome (PCAS), characterised by oxidative stress, coagulopathy, neuronal injury, and organ dysfunction.... read more
Corticosteroid Therapy for Critically Ill Patients with the MERS
Corticosteroid therapy in patients with Middle East Respiratory Syndrome (MERS) was not associated with a difference in mortality after adjustment for time-varying confounders, but was associated with delayed MERS coronavirus... read more
50 Years of Research in ARDS
Mechanical ventilation (MV) is critical in the management of many patients with the acute respiratory distress syndrome (ARDS). However, MV can also cause ventilator-induced lung injury (VILI). The selection of an appropriate... read more
Challenges and Opportunities for a Precision Medicine Approach to Critical Illness
Precision medicine in critical care is a key part of our present and future. However, many challenges limit its application for all patients in the ICU. Complex acute illness among patients with multi-morbidity, integrated... read more
Pearls and Pitfalls in Comprehensive Critical Care Echocardiography
Comprehensive critical care echocardiography is a useful, rapid and non-invasive method to both diagnose pathology and monitor treatment response in the critically ill. Although growing dramatically in use around the world,... read more
Hospital Factors May Influence NIV Outcomes Even in Low-Evidence Use
Strong evidence supports use of noninvasive ventilation (NIV) for patients with respiratory distress from chronic obstructive pulmonary disease and heart failure – i.e., strong evidence conditions (SECs). A new study of... read more
Perspectives of Survivors, Families and Researchers on Key Outcomes for Research in ARF
There is heterogeneity among the outcomes evaluated in studies of survivors of acute respiratory failure (ARF). Patient, family and researcher groups supported inclusion of outcome domains that fit within the PICS framework.... read more
Focus on Ventilation and Airway Management in the ICU
Airway and ventilation management are particularly challenging in the intensive care unit (ICU), and are associated with high morbidity and mortality. Figure summarizes some of the more recent findings from the literature.... read more
Higher PEEP versus Lower PEEP Strategies for Patients with ARDS
Use of higher positive end-expiratory pressure (PEEP) is unlikely to improve clinical outcomes among unselected patients with ARDS. We identified eight randomized trials comparing higher versus lower PEEP strategies, enrolling... read more
Platelets and Multi-Organ Failure in Sepsis
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more... read more
The World Day of the Critical Lung Event
On November 17th 2017, the first edition of "The World Day of the Critical Lung" will be held. It will be an online, global, free, bilingual (Spanish and English) participatory and non-profit event organized by the Pan American... read more
Gas Exchange in ARDS
Acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas exchange. Hypoxemia is mainly due to intrapulmonary shunt, whereas increased alveolar dead space explains the alteration of CO2 clearance.... read more
Understanding Patient Outcomes After ARDS
We identified four post-ARDS outcome subtypes that were predicted by sex, ethnicity, pre-ARDS smoking status and other baseline factors. These subtypes may help develop tailored rehabilitation strategies, including investigation... read more
4m-gait speed test reliable/valid physical function measure in ARDS survivors
The 4-m gait speed is a reliable, valid, and responsive measure of physical function in acute respiratory distress syndrome survivors. The estimated minimal important difference will facilitate sample size calculations for... read more
Steroids for severe CAP. Should I?
Steroids. I always have mixed feelings about them. It's a Love & Hate relationship inside my head. On one hand I cannot stand those who claim steroids are the critical care's Holy Grail. Steroids for sepsis, ARDS, trauma,... read more
Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium
Delirium was associated with memory impairment and PTSS-14 scores suggestive of PTSD, but not illness severity. 181 subjects were included. Illness severity did not correlate with delirium duration. On logistic regression,... read more
