HSV-1 Reactivation Associated with Increased Mortality Risk and Pneumonia in COVID-19 Patients

HSV-1 Reactivation Associated with Increased Mortality Risk and Pneumonia in COVID-19 Patients

Critically ill COVID-19 patients frequently reactivate HSV-1 but not HSV-2. HSV-1 reactivation in critically ill COVID-19 patients was associated with an increased risk of day-60 mortality and hospital-acquired pneumonia... read more

ARDS and High Blood Endocan Profile During COVID‑19

ARDS and High Blood Endocan Profile During COVID‑19

With great interest, we read the recently published paper by Pascreau et al. concluding that a high blood endocan profile during COVID‑19 distinguishes moderate from severe acute respiratory distress syndrome (ARDS). In... read more

Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise

Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise

Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality... read more

The Effect of Lowering Tidal Volume on Mortality

The Effect of Lowering Tidal Volume on Mortality

The use of low tidal volume (4-8 ml/kg of predicted body weight) has been considered the default way to ventilate patients with acute respiratory distress syndrome (ARDS) to minimize ventilator-induced lung injury (VILI).... read more

miR-221-5p-Mediated Downregulation of JNK2 Aggravates ALI

miR-221-5p-Mediated Downregulation of JNK2 Aggravates ALI

Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy... read more

Metabolomic Diferences: COVID-19 vs. H1N1 Influenza in ARDS

Metabolomic Diferences: COVID-19 vs. H1N1 Influenza in ARDS

This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in acute respiratory distress syndrome (ARDS). Our findings support the concept that ARDS is associated... read more

Safety and Efficacy of MUST-ARDS

Safety and Efficacy of MUST-ARDS

This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more

COVID-19 Infection Triggers Profibrotic Macrophage Responses and Lung Fibrosis

COVID-19 Infection Triggers Profibrotic Macrophage Responses and Lung Fibrosis

COVID-19-induced acute respiratory distress syndrome (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyzed... read more

Essentials of Aerosol Therapy in Critically Ill Patients

Essentials of Aerosol Therapy in Critically Ill Patients

This book assesses the most appropriate forms of aerosol therapy for critically ill patients. Aerosol therapy is applied for the treatment of several pulmonary diseases in addition to some promising applications intended... read more

ARDS vs. PseudoARDS – Failure of the Berlin Definition

ARDS vs. PseudoARDS – Failure of the Berlin Definition

True ARDS might be defined as a histological diagnosis involving diffuse alveolar damage throughout the lungs (characterized by hyaline membrane formation and thickening of the alveolar walls). PseudoARDS refers to patients... read more

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

During the last decade, experimental and clinical studies have demonstrated that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs... read more

COVID-19 Handbook: Navigating the Future of Healthcare

COVID-19 Handbook: Navigating the Future of Healthcare

The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more

Longitudinal Respiratory Subphenotypes in COVID-19 Patients with ARDS

Longitudinal Respiratory Subphenotypes in COVID-19 Patients with ARDS

COVID-19-related ARDS has no consistent respiratory subphenotype. Patients diverged from a fairly homogenous to a more heterogeneous population, with trajectories of ventilatory ratio and mechanical power being the most discriminatory.... read more

Continuous Positive Airway Pressure and Pronation Outside the ICUs in COVID-19 ARDS

Continuous Positive Airway Pressure and Pronation Outside the ICUs in COVID-19 ARDS

Continuous positive airway pressure with patient mobilization (including pronation) was effective and safe in patients with ARDS due to COVID-19 managed outside the intensive care unit setting during the pandemic. Of 90... read more