Tag: ARDS
Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients
In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more
Outcomes of ECMO in ARDS in Pediatric Trauma Patients
Among children who suffer from acute respiratory distress syndrome (ARDS) complications following trauma, the use of extracorporeal membrane oxygenation (ECMO) failed to show any association with mortality benefit. More... read more
Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS
The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more
Low-Frequency Ventilation May Facilitate Weaning in ARDS Treated with ECMO
Low-frequency ventilation is comparable to conventional protective ventilation in patients with ARDS who have been treated with ECMO. However, low-frequency ventilation may support weaning from invasive mechanical ventilation... read more
A prediction model for nonresponsive outcomes in critically ill patients with ARDS undergoing prone position ventilation
In this study, a risk prediction model for nonresponse to prone position ventilation in acute respiratory distress syndrome (ARDS) patients was constructed, which demonstrated good predictive value and clinical utility. Early... read more
Predictors of High-flow Nasal Cannula Failure in COVID-19 Patients
A retrospective cohort study was conducted during the months of March and May 2021. Data collection was based on a follow-up of 156 hospitalized patients with a diagnosis of COVID-19 who were users of high-flow nasal cannula... read more
How does high fowlers position help with ventilation?
The High Fowler's position, characterized by an inclination of 60-90 degrees, significantly enhances ventilation by optimizing lung expansion and improving respiratory mechanics. This position is particularly beneficial for... read more
COVID-19 ARDS Patients vs. Patients with ARDS
Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS... read more
Early Reapplication of Prone Position During VV-ECMO for ARDS
A combination of prone positioning (PP) and venovenous extracorporeal membrane oxygenation (VV-ECMO) is safe, feasible, and associated with potentially improved survival for severe acute respiratory distress syndrome (ARDS).... read more
Endothelial Activation and Microcirculatory Disorders in Sepsis and Critical Illness
The endothelium is one of the largest organs in the human body and lines the blood vessels and microcirculation of all the vital organs. As such, it functions as a massive and critical surveillance system to orchestrate recognition... read more
Pitfalls in the Management of Mechanical Ventilation: ARDS and Hypermetabolic States
Mechanical Ventilation (MV) is an invaluable, lifesaving therapy for patients with acute respiratory failure, but it must be individualized for each specific underlying physiologic derangement to maximize benefits and minimize... read more
Pressure Support Ventilation During ECMO Support in Patients with ARDS
In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed... read more
Navigating the Complexity of ECMO and Positioning in ARDS Treatment
We read with great interest the network meta-analysis by Sud et al. comparing venovenous extracorporeal membrane oxygenation (VV-ECMO), prone positioning, and supine mechanical ventilation in patients with severe hypoxemic... read more
Another Perspective on Tidal Volume: From Statistics to Uncertainty
We have read with great interest the recent editorial by Pellegrini et al. Undoubtedly, now more than ever, we have begun to question the true role of tidal volume (VT) in acute respiratory distress syndrome (ARDS). As... read more
Prevalence and Survival of Prolonged VV ECMO for ARDS
The understanding of prolonged venovenous extracorporeal membrane oxygenation (VV ECMO) in the setting of acute respiratory distress syndrome (ARDS) is evolving and durations of support once considered extreme are now commonplace.... read more
PEEP May Cause Harm in Less Severe ARDS
A higher positive end-expiratory pressure (PEEP) strategy may cause harm in adult patients with acute respiratory distress syndrome (ARDS) whose subphenotype is characterized by less inflammation and lower severity of illness. The... read more
Ketones Alleviates COVID-19-related ARDS
In this randomized controlled trial, supplementation with beta-hydroxybutyrate improved inflammatory biomarkers and reduced the length of hospitalization in adults with COVID-19–related acute respiratory distress syndrome... read more
Dexamethasone Systemic Effects in Severe COVID-19
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk... read more
Emergency Department Disposition and Mortality in COVID‐19 Patients with ARDS
Compared to direct ICU admission, admission from the ED to the ward is associated with increased mortality in patients who meet COVID‐19 ARDS criteria during their hospitalization, despite lower 4C and similar SAPS‐III... read more
Endothelial Dysfunction and Persistent Inflammation in Severe Post-COVID-19 Patients
Six months after ICU discharge from severe ARDS secondary to COVID-19, patients with gas exchange impairment exhibit evidence of systemic inflammation, along with elevated ICAM-1 levels, ultimately resulting in increased... read more
BARDA Selected Host-directed Therapeutic Candidates to Address ARDS
Biomedical Advanced Research and Development Authority (BARDA) has selected host-directed therapeutic candidates for inclusion in a phase 2 platform clinical trial to address acute respiratory distress syndrome (ARDS). Currently,... read more
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS
The extended lung protection with strict control of ΔP for moderate to severe ARDS plus deranged mechanics is feasible and could be implemented in this pilot study with some beneficial impact on the recovery of lung function.... read more
