Non-invasive Respiratory Support and P-SILI in COVID-19

Non-invasive Respiratory Support and P-SILI in COVID-19

Coronavirus disease 2019 (COVID-19) pneumonia is associated with hypoxemic respiratory failure, ranging from mild to severe. Due to the worldwide shortage of intensive care unit beds, a relatively high number of patients... read more

COVID-19 ARDS has higher EVLWi and PVPI values than non-COVID-19 ARDS

COVID-19 ARDS has higher EVLWi and PVPI values than non-COVID-19 ARDS

Compared to acute respiratory distress syndrome (ARDS) patients without COVID-19, patients with COVID-19 had similar lung mechanics, but higher extravascular lung water index (EVLWi) and pulmonary vascular permeability index... read more

Steer Clear of Magnesium for COPD

Steer Clear of Magnesium for COPD

Knowingly or not, we in emergency medicine tend to lean into the Dutch hypothesis, a 1960s postulate that asthma and COPD are part of a spectrum of common disease (chronic obstructive lung disease), and should be considered... read more

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation... read more

Precision Medicine in ARDS

Precision Medicine in ARDS

Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for... read more

Early Outcomes After Lung Transplantation for Severe COVID-19

Early Outcomes After Lung Transplantation for Severe COVID-19

The findings from our report show that lung transplantation is the only option for survival in some patients with severe, unresolving COVID-19-associated ARDS, and that the procedure can be done successfully, with good early... read more

Bodily Pain in Survivors of ARDS

Bodily Pain in Survivors of ARDS

Nearly half of acute respiratory distress syndrome (ARDS) survivors reported bodily pain at 6- and 12-month follow-up; one-third reported pain at both time points. Pre-ARDS unemployment, smoking history, and in-ICU opioid... read more

New Therapy Could Protect Lung Function in COVID-19 Patients

New Therapy Could Protect Lung Function in COVID-19 Patients

There is an urgent need for new drugs for ARDS patients, including those with COVID-19. ARDS in influenza-infected mice is associated with reduced levels of liponucleotides (essential precursors for de novo phospholipid synthesis)... read more

Trend and Pattern of 100 ARDS Patients Teferred for VV ECMO Treatment

Trend and Pattern of 100 ARDS Patients Teferred for VV ECMO Treatment

Referral to specialized center for venovenous (VV) ECMO treatment should be considered expeditiously in case of refractory ARDS, which is often lethal. Transport of unstable patients, although challenging, is feasible and... read more

Ultrasound Grayscale Analysis in ARDS COVID-19

Ultrasound Grayscale Analysis in ARDS COVID-19

Recent evidence regarding the novel coronavirus disease 2019 (COVID19) is growing in describing the characteristics of this disease, with main focus on lung morphology. Few data are available regarding the peripheral and... read more

Promoting Evidence-Based Practice in ARDS

Promoting Evidence-Based Practice in ARDS

There is a dearth of literature addressing interventions to improve implementation of evidence-based practices in acute respiratory distress syndrome (ARDS). Existing interventions to improve clinician knowledge and facilitate... read more

Remestemcel-L reduces ARDS mortality in those under 65 years old

Remestemcel-L reduces ARDS mortality in those under 65 years old

New data shows patients with COVID-19-related Acute Respiratory Distress Syndrome (ARDS) were up to 75 percent less likely to die when treated with remestemcel-L and dexamethasone. The data shows remestemcel-L reduced... read more

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

In a retrospective analysis of consecutive intubated subjects with moderate or severe ARDS, related or not to COVID-19, spontaneous breathing during prone positioning (PP) was well tolerated and achieved significant improvement... read more

Decreased Mortality in ARDS Patients Treated with Corticosteroids

Decreased Mortality in ARDS Patients Treated with Corticosteroids

The use of glucocorticoids might result in reduced mortality in patients with ARDS. Glucocorticoids might be recommended as an adjunct to standard care for ARDS; however, the optimal dose and duration of steroid therapy remains... read more

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory flow limitation (EFL) is present when the flow cannot rise despite an increase in the expiratory driving pressure. The mechanisms of EFL are debated but are believed to be related to the collapsibility of small... read more

Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients

Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients

COVID-19 patients with pre-existing coronary artery disease represented a higher abnormal percentage of cardiac markers, accompanied by high mortality and ICU admission rate. BNP together with hs-TNI, α- HBDH, CK-MB and... read more

Massive Alveolar Hemorrhage Presenting During the COVID-19 Pandemic

Massive Alveolar Hemorrhage Presenting During the COVID-19 Pandemic

The coronavirus disease (COVID-19) pandemic has challenged healthcare systems and has resulted in complex diagnostic processes for patients with non-COVID-19 pathology. Here, we demonstrate a case of massive alveolar... read more