Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a spectrum of symptoms ranging from mild to critical... read more

Criteria for Selecting COVID-19 Patients for Lung Transplantation

Criteria for Selecting COVID-19 Patients for Lung Transplantation

In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with... read more

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding... read more

Early Outcomes After Lung Transplantation for Severe COVID-19

Early Outcomes After Lung Transplantation for Severe COVID-19

The findings from our report show that lung transplantation is the only option for survival in some patients with severe, unresolving COVID-19-associated ARDS, and that the procedure can be done successfully, with good early... read more

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

The innate immune response is critical for recognizing and controlling infections through the release of cytokines and chemokines. However, severe pathology during some infections, including SARS-CoV-2, is driven by hyperactive... read more

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells

Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and recurrence of PCR-positive tests have been widely reported in patients after recovery from COVID-19, but some of these patients do... read more

Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination

Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination

This study found an association between vaccination with BNT162b2 in hospital employees and a decreased risk of symptomatic and asymptomatic infections with SARS-CoV-2. Limitations include the observational design; short... read more

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

Sabah in Malaysian Borneo is among the Malaysian states which reported a high number of detected COVID-19 cases during the current pandemic. Due to geographical challenges and limited resources, clinicians developed novel... read more

COVID-19: Convalescent Plasma vs. Standard Plasma

COVID-19: Convalescent Plasma vs. Standard Plasma

Administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome. Enrollment... read more

Guidance on COVID-19 Clinical Care and Treatment by Specialty

Guidance on COVID-19 Clinical Care and Treatment by Specialty

We are providing these links as part of our support to members seeking specialty advice for specific medical conditions, particularly those outside their own specialty. The situation is a fast-evolving one, and while we will... read more

Undercover Epicenter Nurse: How Fraud, Negligence, and Greed Led to Unnecessary Deaths at Elmhurst Hospital

Undercover Epicenter Nurse: How Fraud, Negligence, and Greed Led to Unnecessary Deaths at Elmhurst Hospital

What would you do if you discovered that the media and the government were lying to us all? And that hundreds, maybe thousands of people were dying because of it? Army combat veteran and registered nurse Erin Olszewski’s... read more

New Therapy Could Protect Lung Function in COVID-19 Patients

New Therapy Could Protect Lung Function in COVID-19 Patients

There is an urgent need for new drugs for ARDS patients, including those with COVID-19. ARDS in influenza-infected mice is associated with reduced levels of liponucleotides (essential precursors for de novo phospholipid synthesis)... read more

Persistent Neuropsychiatric Symptoms After COVID-19

Persistent Neuropsychiatric Symptoms After COVID-19

The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of... read more

Ultrasound Grayscale Analysis in ARDS COVID-19

Ultrasound Grayscale Analysis in ARDS COVID-19

Recent evidence regarding the novel coronavirus disease 2019 (COVID19) is growing in describing the characteristics of this disease, with main focus on lung morphology. Few data are available regarding the peripheral and... read more

Remestemcel-L reduces ARDS mortality in those under 65 years old

Remestemcel-L reduces ARDS mortality in those under 65 years old

New data shows patients with COVID-19-related Acute Respiratory Distress Syndrome (ARDS) were up to 75 percent less likely to die when treated with remestemcel-L and dexamethasone. The data shows remestemcel-L reduced... read more

Effect of Neuromuscular Electrical Stimulation on the Recovery of COVID-19 Patients

Effect of Neuromuscular Electrical Stimulation on the Recovery of COVID-19 Patients

The rehabilitation of patients with COVID-19 after prolonged treatment in the intensive care unit is often complex and challenging. Patients may develop a myriad of long-term multiorgan impairments, affecting the respiratory,... read more

Use of Procalcitonin During the First Wave of COVID-19

Use of Procalcitonin During the First Wave of COVID-19

A minority of patients presenting to hospital with COVID-19 have bacterial co-infection. Procalcitonin testing may help identify patients for whom antibiotics should be prescribed or withheld. This study describes the... read more