Tag: coronavirus
ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland
Observed trends suggest opposing effects of ICU strain and clinical learning. Further investigation is needed to identify modifiable system factors that could alleviate strain in future epidemics and changes in clinical practice... read more
Pulmonary Embolism in COVID-19 Patients in France
Pulmonary embolism (PE) in the context of coronavirus disease 2019 (COVID-19) appears to be driven largely by inflammation and coagulopathy rather than by traditional risk factors for thromboembolism. Study results suggest... read more
Pediatric Critical Care and COVID-19
We provide early clinical and laboratory data about critical pediatric COVID-19, which suggest a variable disease but generally good outcomes compared with adults. Targets for research include the course of organ failure... read more
Non-Invasive Cardiac Imaging for LVAD and OHT During COVID-19
Considerations for cardiac imaging in the COVID-19 era include thoughtful patient and study selection with a goal to limit the overall number of tests. General recommendations are as follows: Defer routine or low-risk... read more
The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19
COVID-19 related cardiopulmonary failure such as ARDS and cardiogenic shock or massive pulmonary embolism can be successfully supported with ECMO. Judicious patient selection is important to enable maximal benefit and optimized... read more
Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19
Patients with coronavirus disease 2019 (COVID-19) can develop acute respiratory distress syndrome (ARDS), which has been linked to poor prognosis and is a major contributor to patient death. A better understanding of the... read more
Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic
The evaluation and treatment of acute large vessel occlusion stroke present many challenges during the COVID-19 era. It may be difficult to screen stroke patients for COVID-19 symptoms because of encephalopathy or aphasia.... read more
COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis
Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more
Working in ICU is like Flying a Plane: The Secret World of Intensive Care
Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more
Aerosol and Surface Distribution of SARs-CoV-2 in Hospital Wards
In a hospital treating COVID-19 patients, SARS-CoV-2 RNA was found widely distributed in surface and air samples. Contamination was greater in intensive care units (54/124 samples) than general wards (9/114 samples). A... read more
Is it Safe to Look Yet?
As we start to move to the next stage of the COVID-19 pandemic, it feels like a moment to take stock. The country has gone through huge changes to our way of life over the last few months, and those changes have been mirrored... read more
Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure
The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. The... read more
SARS-CoV-2-reactive T Cells in Healthy Donors and Patients with COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to... read more
NICE COVID-19 Rapid Guideline
The purpose of this guideline is to help healthcare professionals deliver efficient planned care while minimising the risk of COVID-19 in the context of increasing or decreasing local prevalence. It also aims to help patients... read more
Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19
Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more
Presence of Genetic Variants Among Young Men With Severe COVID-19
In this case series of 4 young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses. These preliminary... read more
What Nursing Homes Can Teach EMS About COVID-19
Most EMS providers are familiar with long-term skilled nursing facilities, yet most of us don't think much about them. We certainly don't think they can teach us much. Nursing homes have been hit hard by COVID-19 and... read more
Who Gets to Live? How Doctors Make Impossible Decisions as COVID-19 Surges
Triage aims to provide the greatest amount of good for the greatest number, but medical staff are grappling with how to stay true to this principle as coronavirus surges. 18 states are currently in what's considered the... read more
30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath
The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic... read more
Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19
In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more
Review of Viral Testing and Antibody/Serology Testing for COVID-19 for the Intensivist
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) pandemic has led to the rapid development of many diagnostic tests. The initial focus of these tests was on molecular... read more
COVID-19: A Hypothesis Regarding the Ventilation-Perfusion Mismatch
We believe that a severe V/Q mismatch underlies the pathophysiology of moderate to severe COVID-19 cases, in which downregulation of ACE2 secondary to viral endocytosis plays a key role. There is low V/Q ratio in areas of... read more
