Cardiopulmonary Resuscitation in the Emergency Department During COVID-19

Emergency medical services (EMS) is called for a 65-year-old man with a 1-week history of cough, fever, and mild shortness of breath now reporting chest pain. Vitals on scene were HR 110, BP 135/90, SpO2 88% on room air.... read more

AKI in Critically Ill Patients with COVID-19

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more

COVID-19 – Effective Triage During a Pandemic

The UK is likely on the brink of a major COVID-19 outbreak. About 6% to 10% of infected people are likely to be critically ill, most of whom will require ventilation support in an intensive care environment. Italy is already... read more

Safe Airway Management for the Patient with COVID-19

In this presentation, Dr Ravi Bhagrath, Consultant Anaesthetist at Bart’s Health, London asks Dr Kariem El-Boghdadly, Consultant in Anaesthesia at Guy's and St Thomas' NHS Foundation Trust, London about the IntubateCOVID... read more

Innovative Approaches to Patient Rehabilitation Maximize COVID-19 Recovery

People hospitalized with COVID-19 can experience debilitating physical changes — extreme fatigue, difficulty breathing and muscle weakness, says April Pruski, M.D., a Johns Hopkins physiatrist (a medical doctor who specializes... read more

Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam

This case demonstrates the importance of rapid recognition and treatment of hydroxychloroquine poisoning. We anticipate that clinicians may be asked to recognize and manage this toxidrome in increasing frequency as attention... read more

Preparing for COVID-19 Related Drug Shortages

The COVID-19 pandemic has dramatically impacted all aspects of healthcare delivery. There is widespread concern that increased clinical demands due to the virus will outstrip available resources. Much attention has focused... read more

Ethnicity and Outcomes in Patients Hospitalised with COVID-19

Preliminary studies suggest that people from Black, Asian and Minority Ethnic (BAME) backgrounds experience higher mortality from COVID-19 but the underlying reasons remain unclear. Prospective analysis of registry data... read more

How and When to End the COVID-19 Lockdown

Countries around the world are in a state of lockdown to help limit the spread of SARS-CoV-2. However, as the number of new daily confirmed cases begins to decrease, governments must decide how to release their populations... read more

Ventilator Management in the Age of COVID-19

In the age of coronavirus disease-19 (COVID-19), conservation of personal protective equipment (PPE) represents an urgent public health priority. Vargas et al. describe a logistic project and organizational plan to prevent... read more

Spotting the Clotting: Hypercoagulopathy in COVID-19

Evolving experience with TEG, clotting parameters, treatment considerations, and ongoing data gathering will help us better understand if antiplatelet therapy with aspirin or clopidogrel or anticoagulant treatment with traditional... read more

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

In this case series of hospitalized children who met criteria for PIMS-TS, there was a wide spectrum of presenting signs and symptoms and disease severity, ranging from fever and inflammation to myocardial injury, shock,... read more

Managing Theatre Processes for Planned Surgery Between COVID-19 Surges

As we emerge from the first pandemic surge, there is a widespread desire to restart planned surgery using patient pathways that seek to minimise COVID-19 risk to patients and healthcare workers (HCWs). Some hospitals... read more

ACEI/ARB Use and Testing Positive for COVID-19

This retrospective cohort study reports that taking either an angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) was not associated with an increase in the likelihood of testing positive... read more

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic... read more

Tube Thoracostomy during the COVID-19 Pandemic

This document provides guidance for trauma and acute care surgeons surrounding the placement, management and removal of chest tubes during the COVID-19 pandemic. Tube thoracostomy for a traumatic hemothorax or pneumothorax... read more

COVID-19: 10 Things I Wished I’d Known Some Months Ago

The COVID-19 pandemic is ongoing and spreading, affecting individuals in over 200 countries now. While COVID-19-related articles are being published every day, including guidelines of optimal clinical management, there are... read more

Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation

Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be facilitated by... read more

Thousands Who Got COVID-19 in March Are Still Sick

COVID-19 has existed for less than six months, and it is easy to forget how little we know about it. The standard view is that a minority of infected people, who are typically elderly or have preexisting health problems,... read more

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more

WHO Resumes Hydroxychloroquine Study for COVID-19

The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more

The Perils of Premature Phenotyping in COVID-19

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented global healthcare challenge. Severe novel Coronavirus disease (COVID-19) pneumonia frequently causes hypoxemic respiratory failure, manifesting... read more