Mechanically Ventilated COVID-19 Patients: Long-term Survival Study

Mechanically Ventilated COVID-19 Patients: Long-term Survival Study

The long-term survival of mechanically ventilated patients with severe COVID-19 reaches more than 50% and may help to provide individualized risk stratification and potential treatments. 868 patients were included (median... read more

Fluvoxamine COVID-19 Treatment: Positive Impact on Patient Survival

Fluvoxamine COVID-19 Treatment: Positive Impact on Patient Survival

Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID-19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID-19 patients are urgently... read more

Cardiac Injury in COVID-19

Cardiac Injury in COVID-19

Patients with coronavirus disease 2019 (COVID-19) can present with a large panel of cardiac manifestations, including myocardial infarction with (type 1) or without (type 2) obstructive coronary artery disease, arterial or... read more

HIV and COVID-19 Increased Risk of Severe Outcomes

HIV and COVID-19 Increased Risk of Severe Outcomes

People living with HIV with detectable HIV viraemia, chronic comorbidities, and some subpopulations could be at increased risk of severe outcomes from COVID-19. These groups should be prioritised in clinical management and... read more

COVID-19-related Death in Fully Vaccinated People in Scotland – Characteristics and Risk

COVID-19-related Death in Fully Vaccinated People in Scotland – Characteristics and Risk

Vaccines are highly effective in preventing COVID-19 hospitalisations and deaths. COVID-19-related deaths in fully vaccinated individuals have, however, been reported. To inform public health strategy and vaccination... read more

Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Among high-risk patients with mild-to-moderate COVID-19, sotrovimab reduced the risk of disease progression. No safety signals were identified. The results of this interim analysis of COMET-ICE indicate that sotrovimab... read more

Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults

Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults

In this study, peripheral blood mononuclear cells from young and old patients with COVID-19 were examined phenotypically, transcriptionally and functionally to reveal age-, time- and severity-specific adaptations. Gene... read more

Risk of Death in Hospitalised COVID‐19 Patients Is Not Reduced by Azithromycin Treatment

Risk of Death in Hospitalised COVID‐19 Patients Is Not Reduced by Azithromycin Treatment

The effect of antibiotics with potential antiviral and anti‐inflammatory properties are being investigated in clinical trials as treatment for COVID‐19. We are certain that risk of death in hospitalised COVID‐19... read more

ABCDEF Bundle Implementation for ICU Patients During the COVID-19

ABCDEF Bundle Implementation for ICU Patients During the COVID-19

Regardless of COVID-19 infection status, implementation rates for the ABCDEF bundle, for each element individually and an ICU diary were extremely low for patients without and with COVID-19 infections during the pandemic.... read more

CAPSID Randomized Trial Results for High-dose Convalescent Plasma in COVID-19 Patients

CAPSID Randomized Trial Results for High-dose Convalescent Plasma in COVID-19 Patients

COVID-19 convalescent plasma (CCP) has been considered a treatment option for COVID-19. This trial assessed the efficacy of a neutralizing antibody containing high-dose CCP in hospitalized adults with COVID-19 requiring respiratory... read more

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

The ongoing pandemic could affect the duration, variety and severity of the mental, physical, and cognitive impairments intensive care unit (ICU) survivors and their families frequently present. We aim to determine the impact... read more

Neurological Complications After First Dose of COVID-19 Vaccines

Neurological Complications After First Dose of COVID-19 Vaccines

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more

COVID-19 and Critical Illness Neuropathy

COVID-19 and Critical Illness Neuropathy

We have described COVID patients in the ICU with critical illness neuropathy (CIP). COVID-related CIP could have implications for the functional recovery and rehabilitation strategies. Nerve conduction studies showed a... read more

Interhospital Transfer of COVID-19 Patients Treated with High-flow Nasal Oxygen Therapy

Interhospital Transfer of COVID-19 Patients Treated with High-flow Nasal Oxygen Therapy

At the start of the COVID-19 pandemic, early intubation was recommended on the basis of worldwide observations of severe hypoxemia. However, some patients were ultimately able to benefit from high-flow nasal cannula (HFNC)... read more

CCSC Encourage Flu Shots Amid COVID-19 Spread

CCSC Encourage Flu Shots Amid COVID-19 Spread

The members of the Critical Care Societies Collaborative (CCSC), which includes the American Association of Critical-Care Nurses (AACN), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and Society... read more

COVID-19: Restricted Visitation Policies in Acute Care Settings

COVID-19: Restricted Visitation Policies in Acute Care Settings

Patients, families, and healthcare professionals were impacted by restricted visitation polices in acute care settings during COVID-19. The consequences of this approach on patients and families are understudied and warrant... read more

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

In this systematic review, we evaluated the temporal progression of clinical abnormalities experienced by patients who recovered from an infection with SARS-CoV-2, starting with a mean of 30 days post–acute illness and... read more