Full Vaccination Suppresses COVID-19 Delta Variant Mutation Frequency

This study presents the first evidence that full vaccination against COVID-19 suppresses emergent mutations of SARS-CoV-2 delta variants. An evolution algorithm, Tajima's D test with a threshold value as -2.50, can provide... read more

Full Vaccination Suppresses COVID-19 Delta Variant Mutation Frequency

NIH-convened Expert Panel Proposes Standardized Definition of Placental COVID-19 Infection

A panel of experts convened by the National Institutes of Health has recommended standardized criteria to define infection of the placenta with SARS-CoV-2, the virus that causes COVID-19. The panel also offers guidance... read more

NIH-convened Expert Panel Proposes Standardized Definition of Placental COVID-19 Infection

COVID-19, Online Shaming, and Health-care Professionals

Stigma and shame have been features of past pandemics. The stigma associated with disease can be experienced as shame by those who spread it. In almost all human cultures, there is shame attached to being “contaminated”,... read more

COVID-19, Online Shaming, and Health-care Professionals

Junior Doctors Write to Young People to Acknowledge Vaccine Concerns

A group of junior doctors from Scotland have written to young people in their age group to try to ease concerns they may have about receiving the covid-19 vaccine. In an open letter sent on Friday 6 August the doctors,... read more

Junior Doctors Write to Young People to Acknowledge Vaccine Concerns

RECOVERY-RS trial finds CPAP reduces need for invasive ventilation in hospitalised COVID-19 patients

The NIHR-supported Respiratory Strategies in COVID-19; CPAP, High-flow, and Standard Care (RECOVERY-RS) trial has demonstrated that treating hospitalised COVID-19 patients who have acute respiratory failure with continuous... read more

RECOVERY-RS trial finds CPAP reduces need for invasive ventilation in hospitalised COVID-19 patients

Adaptive Randomized Controlled Trial of Non-invasive Respiratory Strategies in ARF Patients with COVID-19

Continuous positive airway pressure (CPAP), compared with conventional oxygen therapy, reduced the composite outcome of intubation or death within 30 days of randomisation in hospitalized adults with acute respiratory failure... read more

Adaptive Randomized Controlled Trial of Non-invasive Respiratory Strategies in ARF Patients with COVID-19

Cystic Fibrosis in the COVID-19 Pandemic

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of life-threatening COVID-19 are believed to disproportionately affect certain at-risk populations. However, it is not clear whether... read more

Cystic Fibrosis in the COVID-19 Pandemic

Progressive Increase in Virulence of COVID-19 Variants

The progressive increase in transmissibility and virulence of SARS-CoV-2 VOCs will result in a significantly larger, and more deadly, pandemic than would have occurred in the absence of variants of concern (VOC) emergence. The... read more

Progressive Increase in Virulence of COVID-19 Variants

COVID-19: a boost for intensive care authorship?

Almost 180 million cases of COVID-19 have been diagnosed, with almost 4.000.000 deaths. Since this pandemic had unprecedented worldwide healthcare and socio-economic effects, the scientific world is under exceptional pressure... read more

COVID-19: a boost for intensive care authorship?

Managing Rising COVID-19 Cases in ICU

I have been working in intensive care for over 20 years, including a decade as a consultant, and facing winter pressures has always been the norm. However, the past 18 months have been something else. During the winter... read more

Managing Rising COVID-19 Cases in ICU

Incidence of Arrhythmia Higher in COVID-19 vs. Other CAPs

The incidence of arrhythmia was higher in COVID-19 than in other community-acquired pneumonia (CAP), with 2 out of 10 COVID-19 patients dying after developing arrhythmia. Higher incidence rates of conduction disorders... read more

Incidence of Arrhythmia Higher in COVID-19 vs. Other CAPs

COVID-19 Restructures the Host Chromatin Architecture

SARS-CoV-2 has made >190-million infections worldwide, thus it is pivotal to understand the viral impacts on host cells. Many viruses can significantly alter host chromatin, but such roles of SARS-CoV-2 are largely unknown.... read more

COVID-19 Restructures the Host Chromatin Architecture

Neuropsychiatric Disorders and COVID-19

We read with interest the Article by Maxime Taquet and colleagues1 in The Lancet Psychiatry that evaluated a large population (n=236 379) for neurological and psychiatric complications of COVID-19 via analysis of diagnostic... read more

Neuropsychiatric Disorders and COVID-19

The Gut in COVID‑19

In the last year, a growing number of articles addressed coronavirus disease 2019 (COVID-19), including its link with gastrointestinal (GI) (dys)function. We here highlight the most important findings regarding the role of... read more

The Gut in COVID‑19

Prone Positioning and Survival in Mechanically Ventilated Patients with COVID-19

In-hospital mortality was lower in mechanically ventilated hypoxemic patients with coronavirus disease 2019 treated with early proning compared with patients whose treatment did not include early proning. Among 2,338 eligible... read more

Prone Positioning and Survival in Mechanically Ventilated Patients with COVID-19

Liver Dysfunction and COVID-19 Infection

Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019 (COVID-19), which predominantly affects the respiratory system; it also causes systemic and multi-organic disease. Liver... read more

Liver Dysfunction and COVID-19 Infection

Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization

COVID-19 is linked to clinically relevant psychological distress in a subgroup of patients and their relatives 90 days after hospitalization. If confirmed in an independent and larger patient cohort, knowledge about these... read more

Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization

Moderna Vaccine 94.1% Efficacy Preventing Symptomatic COVID-19

The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants... read more

Moderna Vaccine 94.1% Efficacy Preventing Symptomatic COVID-19

COVID-19 Surges Increased Patient Mortality

A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more

COVID-19 Surges Increased Patient Mortality

Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization

The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more

Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP